Science

🧬 Life Sciences & Medicine Intermittent dialysis fails noninferiority test against continuous therapy in intensive care – A French trial in critically ill adults with acute kidney injury found that starting with intermittent haemodialysis was not shown to be noninferior to continuous renal-replacement therapy, and was associated with higher mortality. Death, dialysis dependence or a […]

🧬 Life Sciences & Medicine Gut bacteria before vaccination tracked with fever after mRNA shots – People whose gut bacteria made more flagellin, the protein that builds bacterial tails, were more likely to run a fever after a COVID-19 mRNA vaccine. The team followed stool samples, oral temperature and blood markers over time, then transferred […]

🧬 Life Sciences & Medicine Asgard archaea crawl across surfaces using actin-dependent protrusions – Two cultured Asgard archaea, the closest known prokaryotic relatives of eukaryotes, were filmed changing shape within minutes and crawling over glass with protrusions that grow and retract at 1.5 to 4.8 micrometres per minute. The team kept the cells oxygen-free under […]

🧬 Life Sciences & Medicine A multicancer blood test did not reduce late-stage diagnoses in a trial – In the randomised NHS-Galleri trial, adding the Galleri blood test to usual care did not lower the rate of stage III or IV diagnoses across 12 prespecified cancers after three annual screening rounds, with an incidence rate […]

🧬 Life Sciences & Medicine A viral protein that guides RNA to DNA predates CRISPR – Researchers identified VIPR systems, in which a protein older than the earliest CRISPR-Cas effectors uses a short RNA to find and silence a matching stretch of DNA. Unlike CRISPR guides, which pair with their target letter by letter, VIPR […]

🧬 Life Sciences & Medicine Base editing fixed a cholesterol gene in human embryos and created new errors – Researchers edited the PCSK9 gene in single-cell human embryos, reaching the intended change in every cell in some experiments. Base editors rewrite one DNA letter without cutting both strands; the team applied them to fertilised eggs […]

🧬 Life Sciences & Medicine Pan-RAS inhibitor shrank tumours in a third of treated lung cancers – Daraxonrasib, an oral drug that binds RAS proteins while they are switched on, shrank tumours in 31 to 37 percent of 136 previously treated patients with metastatic RAS-mutant lung cancer. Among the 38 given 160 to 220 mg, […]

🧬 Life Sciences & Medicine Ketogenic diet cut liver fat most in a 42-person trial – A randomised trial in 42 people with obesity, prediabetes and fatty liver disease found the ketogenic arm lost 67 percent of its liver fat, against about 45 percent on the two comparison diets. All food was provided and each […]

🧬 Life Sciences & Medicine Individualised mRNA cancer vaccine meets its phase 3 endpoints – Merck and Moderna reported that adding intismeran autogene, an individualised mRNA neoantigen therapy, to pembrolizumab lengthened recurrence-free survival after melanoma surgery. The INTerpath-001 trial randomised 1,137 patients with resected stage IIB to IV melanoma 2 to 1, and met its […]